Cornerback Jaylen Armour-Davis has also been ruled out while offensive linemen Tyler Linderbaum and Daniel Faalele are ready to go, according to the team's injury report.
Flowers, who missed practice on Sunday and Monday has been dealing with a lingering shoulder injury. If Flowers isn't able to go, the Ravens will be without their leading receiver for a crucial game.
Flowers leads the Ravens in targets (109), receptions (71), 1,016 (yards), yards after catch (439), and receiving first downs (46).
Hill, who is also having a career year with 611 total yards and four touchdowns, will be replaced by either rookie Rasheen Ali, who saw some time at the end of the team's game against the New York Giants, or fan favourite Keaton Mitchell, who has yet to see a snap at running back this season after coming back from ACL surgery.
This will now make it the second straight week for Agholor on the sidelines. The 10-year veteran has proven to be a nice third option at wide receiver for the Ravens since joining the team in 2023. Rookie Devontez Walker will step up into the number two spot for the Ravens if Flowers and Agholor can't go.
Baltimore recently claimed former Houston Texans wide receiver Steven Sims Jr. off waivers and elevated wide receiver Anthony Miller, also a former Texan, from the practice squad in preparation for the game on Christmas Day.