Moss came out and admitted that he was receiving chemotherapy and radiation for treatment and will continue to be away from ESPN's Sunday NFL Countdown until he recovers.
He also announced during the Instagram Live feed as he was holding himself up with a cane that he had a stent placed on his liver following discoloration in his urine.
"My goal is to get back on television with my team," said Moss.
Moss is now launching a project with the slogan "Let's Moss Cancer" to bring more awareness and resources to cancer research.
The news breaks after recent concerns for his health when fans realized his eyes were extremely yellow during one of his recent appearances on Sunday NFL Countdown, which was followed by his next appearance wearing sunglasses.
The 2018 Hall-of-Fame inductee is second in NFL history with 156 touchdown receptions, fourth in receiving yards (15,292), and 16th in receptions (982).
Many fans and players consider Moss the greatest receiver of all time. He played 14 seasons in the NFL with the Minnesota Vikings, Oakland Raiders, New England Patriots (where he broke the single-season record for touchdown receptions with 23), Tennessee Titans, and San Francisco 49ers.