Here are the talking points ahead of the games.
Kaizer Chiefs vs Red Arrows (Zambia)
CAF Confederation Cup, second round, second leg
Friday, October 23, 18h00 SA time
Certainly the biggest job falls to Chiefs, who trail 1-0 from the first leg against a very good Red Arrows side.
If they concede once, they will need three goals, and that looks a tall order for a side who do not score many.
They faced a similar scenario last season against Angola’s Kabuscorp, having also lost the first leg 1-0, but won by the same scoreline at home in the second and advanced on penalties.
They would take that any day after a difficult first leg and with a poor record in general against Zambian sides.
They have only overturned a first-leg deficit in CAF club competitions once in eight attempts, which was against Kabuscorp.
Overall, their record on their own patch in African club competition is strong, though. They have hosted 36 games and won 25 of them, to go with six draws and five defeats, but two of those losses have come against Zambian sides.
Mamelodi Sundowns vs Wiliete (Angola)
CAF Champions League, second round, second leg
Friday, October 23, 20h00 SA time
Sundowns were held to a 0-0 draw on a dodgy pitch in the first leg in Angola, so are vulnerable to the away-goals rule here. Should Wiliete score, they will need to score twice.
But the Champions League holders have become masters in these types of situations, and at a venue that will help them play their natural attacking game, they should get the job done.
Sundowns have played 109 games at home across all CAF competitions and lost only five, to go with 78 wins and 26 draws. In 91 games in the Champions League, they have scored 183 goals and conceded only 47.
Their three home defeats were against Espérance of Tunisia (1-2 in 2017 and 0-1 in 2024) and CR Belouizdad of Algeria (0-2 in 2021).
They have gone 14 consecutive Champions League home matches unbeaten since the defeat to Espérance in April 2024, winning nine and drawing five.
They have never lost to an Angolan side at home, with three wins and two draws.
Wiliete will likely try to keep them to another 0-0 and take the lottery of penalties, but it will be a long evening for them.
Sundowns will likely be without Teboho Mokoena through injury and could also be missing goalkeeper Ronwen Williams.
Orlando Pirates vs African Stars (Namibia)
CAF Champions League, second round, second leg
Friday, October 23, 20h00 SA time
This should be a fairly routine assignment for Pirates, who lead 1-0 from the first leg in neutral Botswana and should have too much firepower for their Namibian visitors.
Pirates coach Abdeslam Ouaddou will want to make sure of the win first, but with Carling Cup action in midweek and the Soweto Derby next weekend, it is also a chance to rotate his squad.
The Buccaneers have slipped up against lesser sides in the past, not least at this stage in 2025/26 when they were beaten by St Eloi Lupopo on penalties, and a few years prior when they went out to Jwaneng Galaxy.
But they should have no such troubles this time round.
AS Port Louis (Mauritius) vs Durban City
CAF Confederation Cup, second round, second leg
Sunday, October 25, 15h00 SA time
Durban City are in their debut season in African club competition and have done well so far, including a 3-1 win over Mauritian side AS Port Louis in the first leg of this tie.
But they should have been out of sight, having wasted numerous opportunities and then given away a soft away goal that could yet come back to bite them.
They should be too strong for their rivals, though, and coach Eric Tinkler is an old hand at playing on the continent, so will set them up in the right way to get a result.
That will see them through to the group stages and continue their African adventure, which will place pressure on the squad domestically.