The Lions are three-point favourites over the Cowboys with the over-under set at 54.5.
Now, let's get into who our experts picked before we break down the game!
Paul (122-56-1): Cowboys 31-24 Lions
The Cowboys will face a Lions team without Amon-Ra St. Brown and with a very leaky defence that let the team down again during their Thanksgiving loss to the Packers.
No doubt will Detroit be crafty with their offense, but Dallas’ is a tough offense to weigh up against. I fear a small dagger in Detroit’s playoff chances might come on Thursday.
Give me Hunter Luepke’s Cowboys!
Eric (118-60-1): Lions 30-26 Cowboys
The Lions have scored 24 or more points in every home game this season, while the Cowboys have allowed at least 22 points or more in every road game this season.
Despite Dallas rolling into the game with the hot hand, they're 2-4 on the road this season, with those two wins coming against the New York Jets and Las Vegas Raiders. Detroit is coming off a tough loss to the Packers, but they're 3-0 at home this season against bottom-15 defences - the Cowboys rank 29th overall.
Have the Cowboys improved? Absolutely. But the Lions have exchanged one win and one loss through the pass eight games. If they stay on the trend, they'll come away with a win in this game.
The only drawback is the mess of injuries on the Lions offensive line heading into this game.
Miguel (114-64-1): Lions 34-27 Cowboys
Despite the Cowboys' recent winning streak and the Lions' Thanksgiving defeat against Green Bay, this is a must-win for the Lions if they want to stay in playoff contention.
While it's true that Dallas is looking very good on offence, I'm not entirely convinced that they are a team that could beat these Lions.
Ultimately, we all know how inconsistent the Cowboys can be, and that could cost them dearly in a stadium like Ford Field.
Henri (108-71-1): Cowboys 34-24 Lions
Detroit recently lost to the Eagles, went into overtime against the lowly Giants, then took a Thanksgiving L to the Packers - the Lions' magic seems to be fading a little.
Dallas, on the other hand, has been in outstanding form since the tragic death of Marshawn Kneeland. The Cowboys are putting their hearts on the field and fighting for every yard in memory of their lost brother - and this inspiring performance on both sides of the ball will also secure a victory for “America's Team” in the Thursday Night Game.
Game breakdown
There's a reason why this game's over-under is the highest of any other matchup this week - it's a battle of the No. 1 offence (DAL) vs. No. 3 offence (DET).
Dallas has won each of their previous two games by three points while the Lions' past two games have each been decided by seven points.
Their offences are also consistently in sync over the past four weeks, with Detroit putting up a combined 111 points to Dallas' 105.
The Lions have averaged 368.0 yards per game over the past four weeks with just two turnovers. As for the No. 1 offence in Dallas, they've averaged a whopping 411.0 yards per game over the past four games, but have committed seven turnovers.
Cowboys QB Dak Prescott has thrown for at least 320 yards with two touchdowns and one interception in back-to-back weeks. He's now second in the league in passing yards this season with 3,261 paired with 25 passing touchdowns and eight interceptions.
Much like his quarterback, George Pickens also ranks second but in receiving yards (1,142) and is tied for the third-most touchdowns (8) in the league.
But their bright spot may come from tight end Jake Ferguson, who is second in receptions (70) among tight ends, which is also just three fewer than Pickens on the season.
Ferguson's 496 yards aren't much considering his workload. However, his seven touchdowns are tied for the fourth-most in the league, becoming a massive red zone threat for the Cowboys offence.
However, their defence is the opposite. They've given up the third-most points (342), the fourth-most yards (4,514), and have forced only 10 turnovers this season - the fourth fewest in the entire league.
Their defense has seemingly improved due to recent trades and guys coming off the injury report, but they still have yet to have someone reach five sacks on the season.
The last time they faced a quarterback outside the top-10 in being sacked was the Arizona Cardinals in Jacoby Brissett - they couldn't sack him once. Before Brissett, it was Bo Nix, who they also couldn't sack.
So, on the flip side of things, the Lions have an overwhelming advantage with their No. 3 offence.
So how does the Lions' defence stack up against the Cowboys' offence? Detroit's defence ranks 13th in yards (3,794) and 15th in points (274).
They've forced only three more turnovers than the Cowboys' defence, but have recorded the 10th-most sacks (32).
One thing to pay attention to is both of their run defences - Cowboys lead the league in rushing touchdowns (28) and the Lions are right behind them with 25.
Lions running back Jahmyr Gibbs is fourth in rushing yards (1,109) and touchdowns (10), all while being fifth in scrimmage yards (1,416) and third in total touchdowns (13).
If the Lions were to outscore Dallas, it'll come from the offence riding on his back this game, especially if their No. 1 receiver Amon-Ra St. Brown is inactive.
St. Brown is the fifth-leading receiver in the NFL this season with 884 yards and is second in touchdowns (9).
In short, there's a reason why the over-under for this game is huge.
Injury reports
( LP = limited participant in practice / FP = full participant in practice / DNP = did not participate in practice )
Kerby Joseph (S), Kalif Raymond (WR), Brock Wright (TE), and Shane Zylstra (TE) are all inactive for the Lions.
Kayode Awosika (DNP), Amon-Ra St. Brown (DNP), Brian Branch (LP), Taylor Decker (LP), Graham Glasgow (LP), Penei Sewell (LP), and Sione Vaki (LP) are all questionable.
As for Dallas, they'll be without Tyler Guyton (OT) and Trevon Diggs (CB) as both are listed as inactive.
Jadeveon Clowney (LP), Hakeem Adeniji (FP), and Malik Hooker (LP) are all questionable.