As promised, Sweden head coach Peter Gerhardsson made changes to his starting XI, bringing in five fresh faces, including Fridolina Rolfo, who made her first start since injury against Denmark over a month ago, earning her 100th cap.
Germany, who could not rely on a draw to seal first place, made a lightning start, attacking from the first whistle and Jule Brand forced a save out of Jennifer Falk within the first 20 seconds, before a dipping Lea Schuller strike went just wide a minute later.
Kosovare Asllani dragged an effort wide from inside the area as Sweden contributed to the exciting opening, but Germany were quickly back in the ascendency, as Schuller headed over before the opener arrived.
A swift attack through the middle culminated with Carlotta Wamser threading a neat ball through to Brand, who coolly rolled it past Falk to give Germany the lead inside seven minutes.
The German pressure did not relent, but with bodies forward they left themselves exposed at the back just five minutes later.
Rolfo cleared the ball up to Stina Blackstenius, who worked well with Asllani before the captain set the striker racing away, and Blackstenius guided her shot past Ann-Katrin Berger to equalise.
Klara Buhl tested Falk as Germany continued to pose a threat, but it was the Blagult who scored the third goal of the game midway through the first half.
Teenager Smilla Holmberg picked the ball up on the right wing and drove into the penalty area, shrugging off challenges, Sarai Linder came across to make a challenge, only for the ball to ricochet off Holmberg and loop over Berger and into the net.
Things got worse for Germany soon after - Johanna Rytting Kaneryd beat the offside trap and drew Berger before squaring to Rolfo. Her shot was blocked on the line, but by the hand of Wamser, who was shown a straight red card.
The resulting penalty was dispatched by Rolfo, who sent Berger the wrong way to celebrate her 100th appearance with a goal.
Poor distribution from Berger on more than one occasion late in the half presented half-chances for the Swedes, but failing to take them meant the sides went in 3-1 at the break.
Germany coach Christian Wuck went for a damage limitation approach after the break, and his defensive side restricted Sweden to a handful of effort on target in the first 30 minutes of the second half, before Rytting Kaneryd struck an effort straight at Berger.
With 10 minutes to play, Sweden wrapped up the victory once and for all - a cross from the left from Madelen Janogy was knocked back across goal by Rytting Kaneryd to Lina Hurtig, who applied the simple finish.
That goal meant the Blagult became the first team to put four goals past Germany at a Women's EURO, while they extended their unbeaten run to 15 matches.
Another win for Sweden means they finish on the maximum nine points in Group C and will play in Zurich on Thursday, while Germany head to Basel for their last eight match next Saturday.
As things stand, France, England, the Netherlands and Wales are all potential opponents for Sweden. Germany can face any Group D side except the Welsh.