FC Midtjylland will then again go head to head with a familiar opponent in the face of the Icelandic international Orri Oskarsson who left FC Copenhagen to join the Spanish club last year.
FCM finished 20th in the first part of the tournament, from which the top 24 advanced to the knockout stage.
The Top 8 clubs go directly to the round of 16, while numbers 9 to 24 have to go through a playoff round to get among the last 16 in the tournament.
The system is created in such a way that numbers 9 and 10 in the league game can only draw number 23 or 24, numbers 11 and 12 can draw number 21 or 22 and so on.
Thus, the Danish champions already knew in advance that they would be drawn against either Real Sociedad or Galatasaray, who they will face over two games in February.
The two playoff matches will be played on February 13 and 20, respectively.
FCM efforts in the league system resulted in three wins, two draws and three defeats.
The victories came at home on a neutral ground against Maccabi Tel Aviv, at home against Union St. Gilloise and out over Ludogorets, while they earned a single point at home against Hoffenheim and Fenerbahce in the last round.
The Europa League final will be played on May 21 at San Mamés in Bilbao in the Basque Country.