Arne Slot's side have won four of their last five matches against the Seagulls in all competitions (L1), though they have also been knocked out in this round on six of the last nine occasions - and three of the last five.
Liverpool's fourth-round jinx
In fact, since the English top-flight was rebranded in 1992, no club has been knocked out of the FA Cup in round four more than Liverpool (13).
Still ingrained in the Dutchman and his squad's collective memories, too, should be their defeat at Plymouth Argyle at this stage last season, whilst the visitors to Anfield should arrive in a fairly confident mood.
Since the start of 2022/23, Brighton have won more FA Cup away games (seven) than any other side in the competition, and have also won their last three fourth-round ties. On each of those occasions, Premier League opponents have been beaten.
Having reached the fifth round on six occasions since 2017, when they earned promotion, their record is only bettered by Manchester Unitedand Manchester City, who have progressed to round five more often in the same time frame (seven and eight times respectively).
Brighton knocked out holders Liverpool in 2023 - in the fourth round
It was the south-coast side that deposed Liverpool as holders in 2023 at this stage, too, thanks to a 2-1 victory.
Notwithstanding all of the above, Liverpool have got the better of the Seagulls recently, having won four of the last five head-to-heads, and Brighton's current away form could temper any confidence, given that they've only won one of their last six matches away from the AMEX Stadium - in the last round against Man Utd.
In the last six games between the teams, at least one of them has scored two goals, and in five of the six matches, three or more goals have been scored.
That would suggest that a goalless draw is out of the equation, and any visiting supporters looking for an omen will do well to recall that after two of Brighton's previous three FA Cup victories over the Reds, they've gone on to reach the semi-finals at least.
All square after six FA Cup meetings
It's the seventh FA Cup meeting between the teams, and in the previous six, both teams have won on three separate occasions.
Liverpool progressed from the ties played in 1907/08, 1990/91 and 2011/12, and Brighton emerged triumphantly from the 1982/83, 2022/23 and 1983/84 fixtures.
In terms of players to watch, Danny Welbeck could well be worth keeping an eye on. His rocket of a goal in the last round helped to dispose of his old club, Man Utd.
The striker is still scoring goals and utilising all of his experience to help drive his Brighton team on, and if he has a say in this game, not only would it be another feather in his cap, but it would also give Thomas Tuchel the timeliest of nudges with World Cup 2026 just four months away.
Both clubs are struggling with injuries
For the Reds, Hugo Ekitike continues to impress in the absence of Alexander Isak, and with Florian Wirtz beginning to find his rhythm now too, they may hold the keys to opening up Brighton's back line.
With no Champions League playoff to worry about in the days following this game, Slot can at least afford to play his strongest possible side in the hope that the club can immediately banish the memories of last year's Fourth Round debacle.
Jeremie Frimpong is still missing for the hosts, and he's joined on the sidelines by Wataru Endo, Conor Bradley, Giovanni Leoni and Isak, whilst Dominik Szoboszlai is absent after his red card against Man City last weekend.
Fabian Hurzeler has the absences of Stefanos Tzimas, Adam Webster, Solly March and Yassin Abbas Ayari to concern himself with, but the visitors can welcome back Mats Wiefer, however, handing them a big boost in the process.
When are either team at their most vulnerable?
Looking at when either of the teams is at their best or most vulnerable, it would seem that Liverpool comes out of the blocks quickly and also tends to score just before the break, whilst they're at their most potent in the final 15 minutes of matches.
The quarter hour before the break is when they tend to concede more, whilst Brighton are at their weakest as games are coming to a close.
If they've not scored when on top, which generally appears to be in either the opening 15 minutes or the quarter-hour period after the hour mark, then it's advantage Liverpool.
