Lamine Yamal, sidelined three times with groin issues since September, is set for a comeback as Barca return to their home ground after two-and-a-half years, with the club reopening the partially renovated Camp Nou with a reduced capacity.
"He worked very hard these two weeks and I'm really happy (with) what I see," Flick said on Friday about the 18-year-old Lamine, who was released from Spain's squad on November 11th.
Raphinha, out since September with a hamstring injury, is also set to be back, but fellow forward Marcus Rashford is a doubt for Saturday after coming down with a fever, Flick added.
The Barcelona team are happy to return to the Camp Nou for the first time since May 2023, the German coach said.
The Catalans played their home matches over the last two seasons at the Olympic Stadium, where Flick led them to the league title in his debut campaign in 2024/25.
The squad held an open training session at the Camp Nou on November 7th.
"I think we prefer to play in Camp Nou... when we were at the training and I went up the stairs and reached the pitch, it was an unbelievable feeling," Flick said.
"It can give us a really big push in the match because it's very close and the fans... know exactly when the team needs this push."
Second-placed Barca are three points behind Real Madrid in the Spanish top-flight and stand 11th in the Champions League, where they visit Chelsea on Tuesday.
"Game-by-game, this is what we want to do. I know that it's a long, long way till the end of May... we never have doubts about what we want to do, how we want to play and reach our goals," Flick said.
"Last season was the same... we have to look into ourselves and we have to give our best performance in every match."