Defending champions Liverpool get proceedings underway on Friday as they host Bournemouth, while the standout fixture of the opening weekend sees Manchester United take on Arsenal in a blockbuster match-up on Sunday.
See all the major fixtures of the Premier League season here
Premier League teams travelled the world during the summer as they embarked on pre-season tours, getting prepared for the new campaign. Manchester United travelled to the United States, while Arsenal visited Singapore and Hong Kong.
How did every team fare during pre-season?
Teams go into the new season with different goals. Some will tussle for the title at the very summit, but several others will battle it out to survive in England's top division.
What Premier League teams should target this season - Part 1
What Premier League teams should target this season - Part 2
The start of a new season also brings the introduction of several new kits. Liverpool have stolen a lot of the headlines with their stunning new home jersey, while Arsenal's third kit has also received a lot of praise.
Premier League 2025/26 kits: In pictures
The Premier League possesses some of the world's best players as well as some of the world's richest clubs, which equates to some very well-paid players!
Who are the Premier League's highest-paid players?
VAR may not be the most popular thing in football, but it is here to stay. Ahead of the new season, the Premier League announced some tweaks to the system while introducing other new rules.
VAR tweaks to camera access: New rules in the Premier League
If you are into this type of stuff, the new Fantasy Premier League season is fast approaching too, as you battle it out with your friends to prove that you have more football knowledge than they do!