Manchester City were stunned by two late goals to eventually lose 2-1 at home to arch-rivals Manchester United in what was their eighth defeat in 11 games.
City weren't the only title hopefuls to slip up as the 10 men of Liverpool could only earn a point in a 2-2 draw with Fulham, while Arsenal were frustrated in a 0-0 stalemate against Everton.
Elsewhere, Chelsea capitalised with a 2-1 win over Brentford, Tottenham rebounded to thrash Southampton 5-0 and Newcastle downed Leicester 4-0.
With that, it's time for Flashscore to look at who makes the latest Premier League Team of the Week.
Lukasz Fabianski, 8.0 (West Ham)
Lukasz Fabianski made eight saves as West Ham were pegged back to draw 1-1 late on at Bournemouth.
The 39-year-old made a series of key saves but was powerless to stop Enes Unal's stunning free-kick which denied the Hammers all three points.
Antonee Robinson, 8.1 (Fulham)
Fulham boss Marco Silva said it was "difficult to express in words" just how good Antonee Robinson's performance against Liverpool was.
The American set up both Fulham goals but was equally as good the other way on the defensive end.
He recorded a game-high eight duels won, four interceptions and three tackles won.
Trevoh Chalobah, 8.3 (Crystal Palace)
Trevoh Chalobah had a solid showing as Crystal Palace emerged as 3-1 winners on their trip to rivals Brighton.
The former Chelsea man made eight clearances, won four duels and popped up with the game's opening goal after rifling in at close range following a scramble.
Lewis Hall, 8.3 (Newcastle)
Lewis Hall had an impact in two goals in Newcastle's demolition of Leicester.
His clever header back across goal was met by Bruno Guimaraes moments before his deflected cross was nodded in by Alexander Isak.
Ismaila Sarr, 9.1 (Crystal Palace)
Ismaila Sarr was the star of the show as he contributed to all three Palace goals at Brighton while netting two himself.
Sarr's first was a determined header at the back post while he finished his second well after being set through on goal.
Pape Matar Sarr, 8.5 (Tottenham)
A tireless display in midfield from Pape Matar Sarr went a long way in Tottenham's drubbing of Southampton.
The Senegalese made four interceptions, won three tackles and five duels and was rewarded for his efforts with a goal after evading a challenge well.
Elliot Anderson, 8.6 (Nottingham Forest)
Elliott Anderson put in a powerful midfield shift in Nottingham Forest's 2-1 comeback victory over Aston Villa.
The 22-year-old won 13 duels and five tackles and supplied the crucial assist for Anthony Elanga's stoppage-time winner.
James Maddison, 9.1 (Tottenham)
James Maddison enjoyed his evening on the south coast for Spurs, coming away with two goals.
Maddison got the goal glut underway with a composed finish through the goalkeeper's legs inside one minute, then curled in his second shortly before half-time from an acute angle.
Heung-min Son, 10 (Tottenham)
He may have only played the first half against Southampton, but that was all Heung-min Son needed as he scored a perfect 10 rating.
The Spurs captain came away from St Mary's with a goal and two assists to help lift the mood around Ange Postecoglou's side.
Son powered home his effort and teed up Sarr for his goal, before his wonderful ball set Maddison away into the box.
Alexander Isak, 8.9 (Newcastle)
The aforementioned Isak came away with a goal and an assist against Leicester, but it could have been an even bigger haul.
The Swedish striker had multiple chances and converted one in the second half, while notching the assist for Jacob Murphy's goal.
Isak ended the game with four chances completed, six dribbles and seven duels won.
Diogo Jota, 8.6 (Liverpool)
Diogo Jota made a big impact on his return from injury by scoring Liverpool's equaliser in his 12 second-half minutes as a substitute.
Jota showed great composure to evade a challenge before slotting into the corner in what was a hard-fought point against Fulham.