The Dane sought to calm tensions as supporters vented their frustration at the final whistle, before Van de Ven and Spence appeared to ignore Frank's request to acknowledge the fans and headed straight down the tunnel.
"I think that is one of the small issues. We have Micky and Djed who are doing everything they can," Frank said.
"They perform very well so far this season, and everyone is frustrated. We do things in a different way, so I don't think it is a big problem."
The manager remained on the pitch, applauding the crowd to a mixed reaction. Spurs have won one of five home games in the Premier League this season under Frank.
"They (the fans) did everything they could to back us in a game that we didn't perform well in. Chelsea were better than us," Frank said.
"There's no doubt, and I keep saying it, that we have a front four that is new. We have to build together with short turnarounds in games. We'll do that. I'm not in doubt that it will happen."
Spurs' lack of fluency in the final third has become a worrying pattern. They also failed to score and lost to Newcastle United in their last league game on Wednesday, fell 1-0 to Bournemouth in August, and were held to a goalless draw at Monaco last month.
"I think every team I've coached has scored a lot of goals. It will happen again in the future here," Frank added.
Frank has overseen clear progress since last season's struggles under Ange Postecoglou. Tottenham have a chance to respond with back-to-back home games against Copenhagen in the Champions League and Manchester United in the league.