Les Bleus, however, will be without centre-back William Saliba, who is suffering from a hamstring injury and full-back Jules Kounde through a thigh injury as the team gear up for their semi-final clash against Spain on June 5 in Stuttgart, Germany.
They will then take on Portugal or Germany for third place or in a title showdown three days later.
Cherki, 21, has been a standout performer in Ligue 1 this season, contributing significantly to Lyon's attacking prowess after long struggling to fulfil his terrific potential.
Various players - Marcus Thuram, Bradley Barcola, Ousmane Dembele, Desire Doue, Warren Zaire-Emery, Benjamin Pavard, Lucas Hernandez - will come off the Champions League final between Paris Saint-Germain and Inter Milan on May 31.
But motivation will not be an issue, Deschamps believes.
"I don't need to motivate them. Spain are certainly the best European team, if not the best in the world, with players who are extremely high-performing," he said.
"Barca aren’t in the Champions League final, so they'll probably be fresher. Of course, there's Lamine Yamal, who does extraordinary things. But he's not the only one we need to keep an eye on. We know very well that we’re up against one of the best teams, if not the very best, at the international level."