Reyes, 25, hit a 2-0 fastball off former Cy Young Award and Triple Crown winner Chris Sale to put his squad up 1-0 in the bottom of the second.
The Dominican Republic native was hitting a stellar .333 with six home runs and 15 RBI through 18 games down in Triple-A before being called up.
He's been in the Phillies system since 2021, but didn't hit his breakout year in the minors until last season, when he hit .331 with 16 home runs, 67 RBI, and 13 stolen bases in 101 games between Double-A (95) and Triple-A (6).
Reyes was called up ahead of Saturday's game after the Phillies optioned Otto Kemp back down to Triple-A